The Research and Extension (R&E) Program is one of the four major programs that makes CLSU unique, particularly in terms of R&D. Its primary role is to generate and validate new knowledge, information, and technologies, and disseminate and commercialize the same to sustain agro-industrialization in the countryside.

It also plays a major role in helping attain the University's noble goal of improving the educational, cultural, political, and environmental consciousness of the people it serves. As such, it must respond quickly and appropriately to their needs and make information and technologies, program, and services within reach of its intended beneficiaries.