The Quezon City Government, as mandated by the State in the Republic Act No. 7160 or the Local Government Code of 1991, exercises its authority to establish a "dynamic organizational structure and operating mechanism that will meet the priority needs and service requirements of its communities."

Through delegation of responsibilities, Quezon City serves as an arm of the national government in pursuit of the country's social progress and economic development, performing its functions efficiently. To ensure the city's effectiveness on established systems, evaluation and monitoring is regularly conducted to enhance individual and group performance and improve communication between employees and management.

The highest authority in command in the local government is the Office of the City Mayor (OCM), followed by the Office of the Vice Mayor (OVM). Working closely with the Office of the City Mayor are the 3 top City Executives: the Chief of Staff (COS), the Office of the Secretary to the Mayor (OSM), and the Office of the City Administrator (OCA) — whose assistance, advice, and support to the City Mayor are vital in managing the city and its operations. Also serving under the Executive Branch of the Quezon City government are a total of 48 departments, offices, and healthcare institutions, 16 special operating units, and 11 special assistance units for national government agencies (NGAs). Under the Legislative Branch, headed by the Vice Mayor as the presiding officer of the Sangguniang Panlungsod, are 4 offices and 36 City Councilors grouped into 6 congressional districts.

All offices, departments, and units play a crucial role in carrying out the city's initiatives and maintaining order for the benefit of all QCitizens. The Quezon City Government persists in its efforts to improve the quality of living and demonstrates transparency in its operations.

Ang Pamahalaang Lungsod ng Quezon, ayon sa mandato ng Estado sa Republic Act No. 7160 o Local Government Code of 1991, ay ginagamit ang kapangyarihan nitong magtatag ng "dynamic organizational structure and operating mechanism that will meet the priority needs and service requirements of its communities."

Sa pamamagitan ng pagtatalaga ng mga responsibilidad, ang Quezon City ay nagsisilbing katuwang ng pambansang pamahalaan sa pagtataguyod ng panlipunang pag-unlad at kaunlarang pang-ekonomiya ng bansa, at mahusay na ginagampanan ang mga tungkulin nito. Upang matiyak ang pagiging epektibo ng lungsod sa mga umiiral na sistema, regular na nagsasagawa ng evaluation at monitoring upang mapabuti ang performance ng bawat indibidwal at grupo at mapahusay ang komunikasyon sa pagitan ng mga kawani at pamunuan.

Ang pinakamataas na awtoridad sa lokal na pamahalaan ay ang Office of the City Mayor (OCM), na sinusundan ng Office of the Vice Mayor (OVM). Malapit na nakikipagtulungan sa Office of the City Mayor ang 3 nangungunang City Executives: ang Chief of Staff (COS), ang Office of the Secretary to the Mayor (OSM), at ang Office of the City Administrator (OCA) — na ang tulong, payo, at suporta sa City Mayor ay mahalaga sa pamamahala ng lungsod at sa mga operasyon nito. Nagsisilbi rin sa ilalim ng Executive Branch ng pamahalaan ng Quezon City ang kabuuang 48 departamento, tanggapan, at institusyong pangkalusugan, 16 special operating units, at 11 special assistance units para sa national government agencies (NGAs). Sa ilalim ng Legislative Branch, na pinamumunuan ng Vice Mayor bilang presiding officer ng Sangguniang Panlungsod, ay may 4 na tanggapan at 36 City Councilors na pinangkat sa 6 na congressional districts.

Lahat ng tanggapan, departamento, at yunit ay may mahalagang papel sa pagpapatupad ng mga inisyatiba ng lungsod at pagpapanatili ng kaayusan para sa kapakinabangan ng lahat ng QCitizens. Patuloy na nagsisikap ang Pamahalaang Lungsod ng Quezon na mapabuti ang kalidad ng pamumuhay at nagpapakita ng transparency sa mga operasyon nito.